Scientific findings indicate that:

• Postbiotics can regulate the immune response by modulating immune receptors, cytokines, and other inflammation-related mediators.
• Research suggests that postbiotics may support intestinal barrier integrity by increasing the expression of proteins responsible for tight junctions.
• Postbiotics may reduce oxidative stress, which has been linked to components produced during fermentation processes.
• Mechanisms of action include modulation of microbiota functions and metabolites that support gastrointestinal health.
• The authors emphasize that postbiotics demonstrate stability and a favorable safety profile, making them a promising research direction in the fields of immunity and gut health.

Source:

Zdybel K, et al. Postbiotics Formulation and Therapeutic Effect. Nutrients. 2025;17(13):2187.

mdpi.com

Study: Poland, University of Life Sciences in Lublin and the Independent Public Healthcare Institution in Biała Podlaska

Publication: Switzerland, Nutrients (MDPI)

POSTBIOTICS have several advantages over probiotics, including:

• no risk of transferring antibiotic resistance genes,
• no potential for extraintestinal colonization and induction of bacteremia,
• greater safety in patients with reduced immunity.

Probiotics are increasingly used as adjunct therapy in the management of gastrointestinal diseases such as ulcerative colitis (UC). However, safety concerns associated with probiotic use exist, which is why POSTBIOTICS are proposed as an alternative in clinical applications.

POSTBIOTICS demonstrated a stronger impact on microbiota composition compared with probiotics.

Overall, direct comparison between a probiotic and a POSTBIOTIC indicates that both alleviate UC symptoms, but POSTBIOTICS more strongly modulate the gut microbiome and its metabolic functions.

The only difference between these preparations is the viability of bacterial cells.

Source:

Zhang T, Zhang W, Feng C, Kwok L-Y, He Q, Sun Z. Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model. npj Science of Food. 2022;6:53. Author Correction 2023. doi:10.1038/s41538-022-00169-9.

npj | science of food

Study: China, Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot

Publication: United Kingdom, npj Science of Food (Nature Portfolio), published in cooperation with Beijing Technology and Business University (China)

Results of scientific studies indicate that:

• Postbiotics may exhibit immunomodulatory, anti-inflammatory and antibacterial activity and support the function of the intestinal barrier and metabolism.
• The use of postbiotics, even those devoid of live microorganisms, may influence elements of the immune system through modulation of immunological receptors and mechanisms of the innate immune response.

Source:

Martín-Peláez S, Cano-Ibáñez N, Pinto-Gallardo M, Amezcua-Priego J, Pérez-García M, Fontecha J, et al. Effects of a Postbiotic and Prebiotic Mixture on Suckling Rats' Microbiota and Immunity. Nutrients. 2021;13(9):3276. PMID: 34578853. NIH | PMID: 34578853

NIH | PMID: 34578853

© NIH | National Library of Medicine | An official website of the United States government.

The results of scientific research indicate that:

• Postbiotics may modulate the immune system by influencing inflammatory cytokines, the activity of innate immune cells, and the production of immunoglobulins.
• Preclinical and clinical studies suggest that postbiotics may support the integrity of the intestinal barrier, which is an important element in controlling inflammatory processes and immunological homeostasis.
• Postbiotics may regulate the gut microbiota and its metabolites, including short-chain fatty acids (SCFA), which affect the functioning of the digestive system.
• Due to their stability, reproducibility of action, and safety, postbiotics are considered a promising area for further research related to immunity, intestinal function, and overall health status.

Source:

Ma L, et al. Postbiotics in Human Health: A Narrative Review. Nutrients. 2023.

NIH | National Library of Medicine

Study: China, Nanchang University

Publication: Switzerland, Nutrients (MDPI)

The results of scientific studies indicate that:

• A fermented postbiotic ingredient may influence the course of respiratory tract infections in children, as observed by a milder severity of symptoms such as sore throat, general malaise, and muscle pain.
• In the group receiving the postbiotic, a reduced use of rescue medications commonly used for the common cold was observed, which may indicate a different dynamics of the body’s response during infection.
• Regular supplementation with a fermented postbiotic ingredient may have contributed to a reduction in the number of days with pronounced infectious symptoms, interpreted as an effect associated with modulation of the immune response.
• The intervention was well tolerated, and the study did not reveal any significant adverse effects in the studied population.

Source:

Singh RG, et al. Clinical trial on the effects of a yeast-derived postbiotic fermentate on cold and flu-like symptoms in children. Pediatric Research. 2024.

Perdiatic RESEARCH

Study: Canada, KGK Science Inc. (London, Ontario)

Publication: USA, Pediatric Research (Springer Nature)